Ipamorelin

Ipamorelin is a synthetic growth hormone secretagogue peptide that has been studied for its interaction with the growth hormone secretagogue receptor, also known as the ghrelin receptor or GHSR. It belongs to the growth hormone-releasing peptide family and is often described in research literature as a selective GHRP-receptor agonist.

Early experimental research characterized ipamorelin as a selective growth hormone secretagogue with limited observed activity on ACTH and cortisol release compared with less selective secretagogues. In a 1998 study, researchers described ipamorelin as the first GHRP-receptor agonist with selectivity for growth hormone release similar to growth hormone-releasing hormone.

The growth hormone secretagogue receptor itself is involved in multiple biological pathways, including growth hormone release, appetite-related signaling, glucose and lipid metabolism, gastrointestinal motility, cardiovascular signaling, neuronal signaling, and immune-function research.

Specifications

Molecular Formula: C38H49N9O5
Molecular Weight: 711.9 g/mol
Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
Primary Research Target: Growth hormone secretagogue receptor / ghrelin receptor
Compound Class: Growth hormone secretagogue peptide

Ipamorelin Research

Ipamorelin and Growth Hormone Secretagogue Receptor Research

Ipamorelin has been investigated for its ability to activate the growth hormone secretagogue receptor. This receptor is closely associated with ghrelin signaling and may influence growth hormone release through hypothalamic and pituitary pathways. Unlike some earlier growth hormone-releasing peptides, ipamorelin has been studied for a more selective signaling profile.

Ipamorelin and Selectivity Research

One of the main research interests surrounding ipamorelin is its selectivity. In early animal and experimental studies, ipamorelin appeared to stimulate growth hormone release while showing limited effect on ACTH and cortisol markers, even at levels substantially above those needed to influence growth hormone release. This selectivity made ipamorelin an important reference compound in growth hormone secretagogue research.

Ipamorelin and Metabolic Pathway Research

Because GHSR signaling is connected to glucose metabolism, lipid metabolism, appetite-related pathways, and gastrointestinal function, ipamorelin has been used as a research compound for exploring how ghrelin-receptor activation may influence broader endocrine and metabolic systems. These mechanisms remain dependent on the experimental model, receptor expression, and study conditions.

References

Raun K, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998.

Yin Y, Li Y, Zhang W. The growth hormone secretagogue receptor: its intracellular signaling and regulation. Int J Mol Sci. 2014.

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